Avast Torrents Assessment

Avast torrents has a dedicated kill move feature, which usually kodi avast stops your true IP via being leaked out while downloading it. The antivirus security software has been produced to protect p2p computers, so it has worked to shield this important aspect of bittorrenting. Avast uses eight private dedicated P2P servers, all of which have rigid reliability methods and wipe-out swap technology. Furthermore, Avast detects false torrents and other malicious documents on your pc.

Avast’s ruisseau service supports P2P design downloads, which are highly secure, and does not keep any digital footprint. The antivirus offers anti-adware and anti-spyware safeguard, this means you will protect you from unnecessary advertisements and tracking. The antivirus offered for free, and it in addition offers a totally free trial version, which you can use for up to 2 weeks without any obligations.

Avast has made P2P-style downloads explicit having its torrents. It includes eight committed P2P servers and keeps your IP address personal. You don’t need to start up VPN to download torrents, and you avoid have to worry about traffic monitoring or monitoring who is monitoring your actions. Avast ruisseau also offer a free trial version, which is ideal for anyone who wishes to test the waters prior to paying for an entire version.

Torrenting can be a trouble for most users. To ensure essential safety, it’s important to use an anti-virus that supports P2P designs. This approach, you won’t need to worry about malicious content that can affect the computer’s overall performance or your privacy. Avast’s 8 P2P servers are safe and secure, which is a great feature when searching for ruisseau. However , you should keep in mind that ruisseau can be hazardous if you don’t have an anti-virus or anti-virus solution.

Web site design For Business Websites

The importance of any good webdesign for a internet business website may not be stressed enough. It can help a little business operate around the clock. With a web-site, customers can access your web store each time. Being obtainable all the time produces a win-win https://panremmuswebdesign.co.uk/how-it-works-and-how-to-choose-a-website-design-service circumstances for a developing business. Yet , a good webdesign isn’t enough. It needs to be user-friendly, using and in a position to deliver the data that a possible client is looking for.

Ensure that your website has a strong design. A good business website can answer any kind of queries buyers may experience and make this easy to make purchases. It should also offer several repayment options to your customers. The consumer should be able to produce a repayment quickly. The final step in getting a small business web designer is to properly review their stock portfolio. A website needs to be functional and user-friendly towards the point which it makes customers want to go back and purchase goods.

Moreover, your web site should be simple to navigate and simple to use. A small company web designer will need to offer you a selection of options to choose from. Consider the features that your customers will need in a site and hire an online design enterprise that offers all of them. A good web development company will be able to meet your expectations. If you fail to decide on the kind of website you want, minimal a portfolio. A stock portfolio will help you determine their encounter level. Take a look at past jobs and see how well they have seen and performed intended for other clientele.

Methods to Uninstall Avast From Your PC

If you want to clear out Avast from your COMPUTER, you need to do away with it first. This malware software may interfere with the day-to-day activities and even make your computer inoperable. It can also affect your system. Luckily, it is easy to total av uninstall it using the Microsoft windows Settings menu. Here are a few steps you may follow. The first step is to drive to the Control Panel and open the Apps and Features window. Select Avast Antivirus, and next select Do away with.

The next step is to delete pretty much all files and settings connected with Avast. Recognize an attack uninstall virtually any applications that will be running as well, as these may cause a problem. You should remove virtually any leftovers from your computer. Once you could have removed this program, you need to re-order it. Avast antivirus is installed on your PC through Windows’ Secureness Center, so you can safely take it off without influencing the security of your computer.

To completely uninstall Avast antivirus, visit the Control Panel and open the Programs and Features eye-port. In the Courses and Features window, select the Avast antivirus security software. Afterward, you must click on the Uninstall button. After getting clicked on it, you will see a screen with several options to change Avast. After selecting the suitable options, the solution will start uninstalling itself. You simply must restart your computer to complete the process.

McAfee For Business Review

The McAfee for business product is a good choice for the purpose of small businesses. https://www.mobilkereso.net/reviews/netflix-vpn It offers many features to assist protect the network against malicious hazards. It has multiple firewall security options and may keep your network protected by identity fraud and malware. It is security features allow you to focus on running your company instead of worrying about malware and other dangers. You may also connect to protect sites on line to protect your data from internet attacks. With the many benefits, this is the choice for small businesses.

McAfee for business provides primary-class antivirus, malware, and contamination protection. Manufactured by computer protection experts, this product can find and get rid of potential threats before they have a chance to cause any damage. It also constantly works files meant for infections, which means that it may provide real-time safety and restoration. It is multiple-device protection and live support help to make it an ideal choice for businesses of all sizes.

McAfee for people who do buiness is free to install and doesn’t need additional reliability products. It comes with multiple updates weekly, is highly personalized, and seems to have centralized capabilities. It can manage a wide variety of dangers automatically. It also has a Techmaster who are able to troubleshoot any issues slightly. Those with concerns can also makes use of the live support option. The McAfee for people who do buiness is a superb choice to get small businesses.

Kaspersky Internet Secureness Review

A free variation of Kaspersky Internet Protection can secure up to twenty devices. The premium version adds twenty more products to the list. Users can also choose to study their computers automatically by specified moments, after program start-up, or right after every app Full Report bring up to date. The cost-free version is included with several useful features. Read on for more information on the best highlights of Kaspersky. This review will handle the pros and cons of Kaspersky. Coming from listed these people below.

Kaspersky have been hit by a controversy more than its ties to the Russian FSB, that this company actively denies. About 13 Sept 2017, the U. Ings. Department of Homeland Security banned Kaspersky products use with government departments. This company denied it turned out responsible for cyber-terrorist stealing info from a great NSA contractor’s home computer. That did, nevertheless , report it had detected malware examples from the Formula Group and uploaded those to its computers.

While Kaspersky is a respectable name in the business, the recent scandal surrounding it is association with Russian cleverness agencies has left the company’s status in fragments. Still, Kaspersky’s antivirus protection features performed well in tests, turning it into a viable approach to home and business users. The organization offers antivirus security for MacOS, Windows, iOS, Android, and Linux, and it’s really user-friendly and has an eye-catching interface. As being a privacy-protection alternative, Kaspersky also stacks up favorably with other top-notch antivirus programs.

Avast Secure Internet browser Review

Avast Protect Browser can be described as web browser by Avast Software. Since its discharge in 2016, it has been incorporated with the installation of Avast Antivirus and can also be downloaded separately through the company’s website. Based on the Chromium project, it is available just for Microsoft Windows, macOS, iOS, and Android devices. Irrespective of being a download free, it may be worth considering a trial before getting.

Avast Protected Browser is mostly a free download https://www.shadowkeepzine.org/complete-review-of-oremus-bible-browser that is appropriate for several operating systems. It works very well with a Home windows PC and it is compatible with Microsoft Advantage, Google Chrome, Firefox, and Ie. It can be used otherwise you default web browser, and it can importance bookmarks and settings from the other browsers as well. It’s appropriate for most of the significant web browsers and has many advanced features. To put in Avast Protect, you will need to set up Avast’s various other security goods.

Avast Protect Browser is certainly free will not not really slow down the device. The advanced reliability features stop you safe online. It will likewise help safeguard your privateness by obstructing harmful websites and spyware. It is going to keep your personal data secure and will secure your id from fraudulence. Avast Secure Browser is available for Windows 7, eight, and 15. You can also find a totally free trial version and read user reviews to learn more about this. It’s easy to mount and comes with a customer support video if you run into any problems.

Avast Free Ant-virus Review

Avast Totally free Antivirus is a wonderful decision for users who is not going to want to shell out money over a full rendition of the merchandise. Designed to protect your computer against malware, it also offers efficiency and reliability scanning, as well as a scan scheduler. A basic study finds problems with the network, outdated program, weak passwords, and destructive browser add-ons. Its advanced scan can detect malicious links and quit downloads before they get started on.

The Avast Antivirus download offers solid protection against fresh threats. The cloud-based reliability technology and machine learning combine to scan your computer with respect to malware. The program’s reader compares suspicious files to a repository of noted malware, and any that it finds can be uploaded to Avast’s research laboratory for analysis. Despite their free type, Avast presents adequate safeguard. The free of charge version offers extensive FAQs and standard customer support.

Avast Free Antivirus exists for free for the Google Perform store. The technology will down load in a few mere seconds and perform virus works on your computer. Once you have finished, Avast will refocus you to its payment web page. If you decide to purchase the product, it could worth the tiny fee to acquire a good malware. Avast is additionally well worth a go. It offers enough protection and it is affordable https://viprereview.com/ for the regular user.

Protegent Antivirus Review

If you want to safeguard your computer right from viruses, spyware and other web based threats, Protegent is the best choice. It provides 24/7 support and will improve your system overall performance. The free variation comes with several benefits, including email protection. It can stop scam attacks and blocked vicious web pages, while the paid release offers other gaming features. It protects your PC coming from worms and other cyber hazards. And, the technology will upgrade itself just about every hour, therefore you’re always protected.

Protegent Antivirus includes four repayment plans and 4 levels of coverage. The cost-free version is limited to 3 devices, and it only protects against malware. The Protegent antivirus will stop spam e-mails, prevent you from going to compromised websites, and take away annoying advertisings. This is a great choice if you’re concerned about privacy or perhaps security. It also comes with a spyware and adware scanner, so that you can be sure your personal computer is covered right from any cyber-attacks.

In addition to virus safeguard, Protegent will find and take away system vulnerabilities and disorders. The company provides a variety of plans and add ons to meet the needs of numerous users. You are able to upgrade your want to get more features, such as a vulnerability scanner. The program will also help protect you unauthorized improvements on your system. The security feature is particularly useful if your computer is at risk of theft. Additionally , it will secure your data and maintain your https://www.onedatablog.com/protegent-antivirus-review-can-it-guarantee-your-full-protection/ system recent.

How Eco Style Can Transform your life Life

The principles of eco design and style are regarding creating the environment with purpose. They involve the beliefs https://abundanceinbalance.com/landscape-design-services-improve-your-next-commercial-landscaping-project of environmental sustainability and the notion of green and sustainable style. The way focuses on creating physical objects, the built environment, and products and services that are environmentally friendly. It also contains the philosophy of employing materials which might be recycled and made from green sources. In addition to applying green and sustainable supplies, eco design is also significant in the structure industry. Read on to learn about some of the ways that eco style can increase the world who are around you.

The first step to sustainable style is to reduce materials utilised in the creation of a goods and services. There are several solutions to do this. One strategy is to reuse parts or materials. For instance , you can use classic car auto tires for boat protection or perhaps replace shattered parts with upgraded systems. Recycling can also be an important part of ecosystem design. Apart from products, divulgación design also incorporates environmental ideas into the process of developing a home. The result is a far more comfortable, environmental living space for everyone and the environment.

Eco style also contains the theory of in order to reduce energy consumption. If you would like to make your property more energy-efficient, choose a services that stocks your prices. The same guideline can be used on moving around village. The most earth-friendly solutions might typically increase the social aspect of your life. The social aspect of eco style is also important. People who benefit these figures is often more likely to pick the product and employ it. The positive social impact is yet another benefit of ecologically design.

Ist Kratom eine natürliche Alternative für Methadon-Ersatztherapien?

Die Hauptanwendung welche Benutzer von Kratom durch alle Regionen und Demographien hindurch als Grund für den Konsum angeben, ist seine Potenz in der Bekämpfung ansonsten behandlungsresistenter Schmerzen. Diese Effekte sind sowohl im Tierversuch und in klinischen Studien belegt (1,2). Mit der Opiatkrise in den USA kam aber auch das Potential Kratoms als natürliches Entzugs-Mittel für Abhängige synthetischer Opioide in den Fokus. Ein wachsender Anteil der Konsumenten in Nordamerika gibt dies als Intention für ihren Kratomkonsum an. Mehrere Studien belegen bei Mäusen und Ratten die Effizienz von Mitragynin (dem Hauptalkaloid im getrockneten Kratom-Laub) im Tiermodell bei der Entwöhnung von Tieren, welche sich zuvor Opiate selbst verabreicht haben. Diversen Autoren zufolge hat es diesbezüglich einen Effekt, der dem von Methadon und Buprenorphin in nichts nachsteht (3,4). In diesem Blogbeitrag wollen wir auf diese Publikationen einen genaueren Blick werfen.

Opiatsucht und Behandlung

Opiatsucht ist in vielen Ländern ein großes Gesundheitsproblem (5,6). Ein wesentlicher Bestandteil der ärztlichen Behandlung sind Massnahmen gegen hochaversive Opiat-Entzugserscheinungen, die ansonsten zu einer Wiederaufnahme der Medikamenteneinnahme führen können. In einer medikamentengestützten Behandlung (MGB) wurden bisher Methadon und Buprenorphin als Substitutionsmittel eingesetzt. Trotz der Wirksamkeit von MGB gibt es immer noch Einschränkungen und starke Nebenwirkungen bei der Verwendung von Methadon und Buprenorphin. Daher sind alternative Therapien mit weniger Nebenwirkungen, geringerem Risiko von Überdosierungen und Begleiterkrankungen erwünscht. Eine potenzielle neue Pharmakotherapie kann das wichtigste Indolalkaloid von Kratom, Mitragynin, beinhalten.

Opiat-Ersatz-Therapie

Die umstrittene Methadontherapie

In der Regel gilt die Methadontherapie als sicher. Die Substanz hat eine lange Halbwertszeit und macht eine ambulante Behandlung möglich. Dennoch sind mehrere Risikofaktoren bekannt: I) Wechselwirkung mit anderen Arzneimitteln, II) Torsade de Pointes (Herzarrhytmien) welche in einem erhöhten Risiko für viele Patienten resultiert, und III) unzureichende oder fehlerhafte Anpassung der Dosis insbesondere bei Verschreibung von Methadon gegen Schmerzen (7). Außerdem zeigt Methadon eine hohe individuelle Varianz in seiner Wirksamkeit aufgrund von pharmakokinetischen und pharmakodynamischen Faktoren (8). Die effektive Halbwertszeit von Methadon zur Analgesie spiegelt bei vielen Patienten nicht die Halbwertszeit für Atemdepression und kardiale Nebenwirkungen wider, was eine konsistente und sichere Dosierung von Methadon erschwert (9). Dies führt oft zu einer Überdosierung, die mit schwerwiegenden Nebenwirkungen verbunden sind, einschließlich potenziell tödlicher Atemwegs-Beschwerden. Tatsächlich sind unbeabsichtigte Todesfälle durch Methadon häufiger als nach Abgabe jedes anderen Opioids (10)!

Methadon

Buprenorphin als Alternative

Eine Alternative zu Methadon ist die Ersatztherapie mit Buprenorphin. Es wirkt als partieller Agonist am mu-Opiaten Rezeptor (MOR) und hat damit ähnlich wie Mitragynin einen „Deckeneffekt“ für Atemdepression. Somit bietet es substantielle Sicherheitsvorteile gegenüber Methadon. Buprenorphin wurde in mehreren Ländern als effiziente und sicherere Therapie für Opiatanhängigkeit zugelassen. Dies führte zu einer Verringerung der Todesfälle im Zusammenhang mit Heroinüberdosierung in Ländern, die diese Therapien eingeführt haben. In Frankreich jedoch wurden mehrere Todesfälle durch Erstickung bei Patienten gemeldet nach Behandlung mit Buprenorphin zusammen mit anderen Arzneimitteln wie Benzodiazepinen. Arzneimittelwechselwirkungen mit Buprenorphin haben eine hohe Inzidenz schwere Atemdepressionen zu verursachen (11).

Kratom zur Linderung von Entzugserscheinungen

Die Kratom-Pflanze (Mitragyna speciosa Korth.) wird schon lange traditionell wegen seiner pharmakologischen Wirkung in südostasiatischen Ländern, insbesondere Thailand und Malaysia verwendet. Konsumenten verwenden Kratom-Pflanzenpräparate für seinen medizinischen Wert bei der Behandlung von Schmerzen, Stimmungsschwankungen, Husten, Durchfall und Darminfektion (12, 13). Kratom wird auch zur Behandlung von Drogenentzugserscheinungen verwendet (14, 15). Kratomblätter beinhalten über 25 pharmakologisch aktive Alkaloide, wobei Mitragynin für den mit Abstand höchsten Anteil verantwortlich zeichnet (16).

Mitragynin wirkt als partieller Agonist am menschlichen Mu-Opioid Rezeptor (MOR) und DeltaOpioid Rezeptor. Es wirkt als kompetitiver Antagonist am menschlichen Kappa-Opioid Rezeptor (17). Insbesondere wurde diesbezüglich gezeigt, dass Mitragynin zwar als Agonist am MOR wirkt, aber Atemdepression, Koma, Lungen-Ödeme und Tod nicht mit menschlichem Kratom Konsum in Verbindung gebracht werden (18). Dies weist auf ein substanziell besseres Sicherheitsprofil von Mitragynin im Vergleich zu klassischen Opiaten wie Morphin hin, bei denen Asphyxie die häufigste Todesursache darstellt. Finden Sie hierzu detailliertere Informationen in unseren Blogbeitrag “Mitragynin & derivative Kratom-Alkaloide: keine klassischen Opiate“.

Die Resultate der hier präsentierten Studie zeigen deutlich, dass die Effizienz von Mitragynin in der Linderung der Entzugserscheinungen von morphinabhängigen Ratten der von Methadon und Buprenorphin in nichts nachsteht:

Studie über Effizienz von Mitragynin

Hierbei ist auch interessant, dass der Effekt von Mitragynin im Gegensatz zu Methadon und Buprenorphin praktisch unabhängig von der verabreichten Dosis auftritt. Er ist zu Beginn am stärksten bei der geringsten Dosis, was die unterschiedlichen dosisabhängigen Pathways der Mitragynin Pharmakologie demonstriert. Die Entzugserscheinungen wurden mit Mitragynin konsistenter und stärker reduziert als mit Methadon und Buprenorphin. Histopathologische und biochemische Tests auf Organschädigungen der Tiere durch Mitragynin fielen zudem negativ aus.

Mitragynin könnte daher sehr wohl eine Option neuer Ersatz-Therapien für Opioidabhängige als Alternative zu Methadon und Buprenorphin darstellen. Da Mitragynin aus Kratomblättern extrahiert wird ist es im Vergleich zu anderen Medikamenten einfacher und kostengünstiger zugänglich. Methadonersatztherapien führen immer noch zu Überdosierung und Todesfällen aufgrund fehlender Obergrenze bei Atemdepression und Sedierung (19). Die nötige Methadon-Dosis variiert zwischen Patienten stark und es ist sehr schwierig, die ideale Dosis zu bestimmen. Auf der anderen Seite ist Buprenorphin potenziell sicherer als Methadon. Als partieller MOR Agonist führt es zudem gleich wie Mitragynin zu weniger körperlicher Abhängigkeit als Methadon. Buprenorphin entwickelt jedoch eine schlechte Retention und ist weniger befriedigend für Patienten, da sie beim Verdrängen von Opiaten sehr starke Entzugserscheinungen verspüren.

Fazit

Zusammenfassend lässt sich sagen, dass im Morphinentzugsmodell bei Ratten die Vier-Tage-Ersatz Behandlung mit Mitragynin die Entzugserscheinungen deutlich abschwächte. Dies deutet darauf hin, dass Mitragynin in der Lage ist, Morphin-Entzugssymptome ähnlich gut wie Methadon und Buprenorphin zu lindern. Die Ergebnisse legen nahe, dass Mitragynin, das wichtigste Indolalkaloid von Kratom, potenziell zur Behandlung von Opiat-Entzug verwendet werden kann. Weitere Forschung einschließlich klinischer Studien ist erforderlich, um die Anwendung von Mitragynin als ergänzende Behandlung von Opioidsucht beim Menschen zu etablieren.

Referenzen

1. Foss, J. D., Nayak, S. U., Tallarida, C. S., Farkas, D. J., Ward, S. J., & Rawls, S. M. (2020). Mitragynine, bioactive alkaloid of kratom, reduces chemotherapy‐induced neuropathic pain in rats through α‐adrenoceptor mechanism. Drug and Alcohol Dependence, 209, 107946. https://doi.org/10.1016/j.drugalcdep.2020.107946

2. Wilson, L. L., Harris, H. M., Eans, S. O., Brice‐Tutt, A. C., Cirino, T. J., Stacy, H. M., Simons, C. A., León, F., Sharma, A., Boyer, E. W., Avery, B. A., McLaughlin, J. P., & McCurdy, C. R. (2020). Lyophilized kratom tea as a therapeutic option for opioid dependence. Drug and Alcohol

3. Hassan, R., Pike See, C., Sreenivasan, S., Mansor, S. M., Müller, C. P., & Hassan, Z. (2020). Mitragynine attenuates morphine withdrawal effects in rats‐A comparison with methadone and buprenorphine. Frontiers in Psychiatry, 11, 411. https://doi.org/10.3389/fpsyt.2020. 00411

4. Hemby, S. E., McIntosh, S., Leon, F., Cutler, S. J., & McCurdy, C. R. (2019). Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine. Addiction Biology, 24, 874–885. https://doi.org/10.1111/adb.12639 4

5. National Institute of Drug Abuse. (2018). Opioid overdose crisis. USA: The National Institutes of Health (NIH). Available from: https://www.drugabuse. gov/drugs-abuse/opioids/opioid-overdose-crisis. 6. Baumann MH, Pasternak GW, Negus SS. Confronting the opioid crisis with basic research in neuropharmacology. Neuropharmacology (2020) 166:107972. doi: 10.1016/j.neuropharm.2020.107972

7. Dinis-Oliveira RJ. Metabolomics of methadone: clinical and forensic toxicological implications and variability of dose response. Drug Metab Rev (2016) 48:568–76. doi: 10.1080/03602532.2016.1192642

8. Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone. Clin Pharmacokinet (2002) 41:1153–93. doi: 10.2165/00003088-200241140-00003

9. Whistler JL. Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend (2012) 121:189–204. doi: 10.1016/j.drugalcdep.2011.10.031

10. Trescot AM, Helm S, Hansen H, Benyamin R, Glaser SE, Adlaka R, et al. Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians’ (ASIPP) Guidelines. Pain Physician (2008) 11:S5–S62.

11. Mégarbane B, Hreiche R, Pirnay S, Marie N, Baud FJ. Does high-dose buprenorphine cause respiratory depression?: possible mechanisms and therapeutic consequences. Toxicol Rev (2006) 25:79–85. doi: 10.2165/ 00139709-200625020-00002

12. Suwanlert S. A study of kratom eaters in Thailand. Bull Narc (1975) 27:21–7. Hassan et al. Mitragynine for Morphine Withdrawal

13. Chan KB, Pakiam C, Rahim RA. Psychoactive plant abuse: the identification of mitragynine in ketum and in ketum preparations. Bull Narc (2005) 57:249–56. 21.

14.Grundmann O. Patterns of kratom use and health impact in the US-Results from an online survey. Drug Alcohol Depend (2017) 176:63–70. doi: 10.1016/ j.drugalcdep.2017.03.007

15. Beckett AH, Shellard EJ, Tackie AN. The Mitragyna species of Asia – Part IV. The alkaloids of the leaves of Mitragyna speciosa Korth. isolation of mitragynine and speciofoline. Planta Med (1965) 13:241–6. doi: 10.1055/s0028-1100118

16. Hassan, Z., Suhaimi, F. W., Ramanathan, S., Ling, K. H., Effendy, M. A., Müller, C. P., & Dringenberg, H. C. (2019). Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats. Journal of Psychopharmacology, 33, 908–918. https://doi.org/10. 1177/0269881119844186

17. Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, et al. Synthetic and receptor signaling explorations of the mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators. J Am Chem Soc (2016) 138:6754–64. doi: 10.1021/ jacs.6b00360

18. Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa Korth). Addiction (2008) 103:1048–50. doi: 10.1111/j.1360-0443.2008.02209.x Dependence, 216, 108310. https://doi.org/10.1016/j.drugalcdep. 2020.108310 $

19. George P, Vicknasingam B, Thurairajasingam S, Ramasamy P, Mohd Yusof H, Yasin MABM, et al. Methadone complications amongst opioid-dependent patients in Malaysia: a case series. Drug Alcohol Rev (2018) 37:147–51. doi: 10.1111/dar.12456